Contribution of scintigraphy to verify the reliability of different preparation processes for enteric coated capsules.
Identifieur interne : 008075 ( Main/Exploration ); précédent : 008074; suivant : 008076Contribution of scintigraphy to verify the reliability of different preparation processes for enteric coated capsules.
Auteurs : RBID : pubmed:8001600English descriptors
- KwdEn :
- Acetaminophen (administration & dosage), Acetaminophen (chemistry), Acetaminophen (pharmacokinetics), Adult, Biological Availability, Drug Compounding (methods), Female, Gamma Cameras, Humans, Indium Radioisotopes (diagnostic use), Male, Middle Aged, Pentetic Acid, Radionuclide Imaging, Solubility, Tablets, Enteric-Coated, Technetium.
- MESH :
- chemical , administration & dosage : Acetaminophen.
- chemical , chemistry : Acetaminophen.
- chemical , diagnostic use : Indium Radioisotopes.
- chemical , pharmacokinetics : Acetaminophen.
- methods : Drug Compounding.
- Adult, Biological Availability, Female, Gamma Cameras, Humans, Male, Middle Aged, Pentetic Acid, Radionuclide Imaging, Solubility, Tablets, Enteric-Coated, Technetium.
Abstract
The aim of this work was to use radiopharmaceuticals such as technetium (99mTc) and indium (DTPA-Ca111In) to visualize, with a gamma-camera, the disintegration area and time of 3 types of enteric coated hard gelatin capsules (obtained by 3 different preparation processes) and thus, to verify that they are really resistant in gastric fluids and soluble in intestinal zones. Results are well correlated with those previously obtained in vitro (disintegration, dissolution) and in vivo (profiles of plasmatic concentrations versus time).
PubMed: 8001600
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Results are well correlated with those previously obtained in vitro (disintegration, dissolution) and in vivo (profiles of plasmatic concentrations versus time).</div></front></TEI><pubmed><MedlineCitation Owner="NLM" Status="MEDLINE"><PMID Version="1">8001600</PMID><DateCreated><Year>1995</Year><Month>01</Month><Day>24</Day></DateCreated><DateCompleted><Year>1995</Year><Month>01</Month><Day>24</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0378-7966</ISSN><JournalIssue CitedMedium="Print"><Volume>19</Volume><Issue>2</Issue><PubDate><MedlineDate>1994 Apr-Jun</MedlineDate></PubDate></JournalIssue><Title>European journal of drug metabolism and pharmacokinetics</Title><ISOAbbreviation>Eur J Drug Metab Pharmacokinet</ISOAbbreviation></Journal><ArticleTitle>Contribution of scintigraphy to verify the reliability of different preparation processes for enteric coated capsules.</ArticleTitle><Pagination><MedlinePgn>91-8</MedlinePgn></Pagination><Abstract><AbstractText>The aim of this work was to use radiopharmaceuticals such as technetium (99mTc) and indium (DTPA-Ca111In) to visualize, with a gamma-camera, the disintegration area and time of 3 types of enteric coated hard gelatin capsules (obtained by 3 different preparation processes) and thus, to verify that they are really resistant in gastric fluids and soluble in intestinal zones. Results are well correlated with those previously obtained in vitro (disintegration, dissolution) and in vivo (profiles of plasmatic concentrations versus time).</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Catteau</LastName><ForeName>D</ForeName><Initials>D</Initials><Affiliation>Laboratoire de Pharmacie Galénique et Biopharmacie, Faculté de Pharmacie, Lille, France.</Affiliation></Author><Author ValidYN="Y"><LastName>Barthélémy</LastName><ForeName>C</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Deveaux</LastName><ForeName>M</ForeName><Initials>M</Initials></Author><Author ValidYN="Y"><LastName>Robert</LastName><ForeName>H</ForeName><Initials>H</Initials></Author><Author ValidYN="Y"><LastName>Trublin</LastName><ForeName>F</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Marchandise</LastName><ForeName>X</ForeName><Initials>X</Initials></Author><Author ValidYN="Y"><LastName>Van Drunen</LastName><ForeName>H</ForeName><Initials>H</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType>Clinical Trial</PublicationType><PublicationType>Comparative Study</PublicationType><PublicationType>Journal Article</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>SWITZERLAND</Country><MedlineTA>Eur J Drug Metab Pharmacokinet</MedlineTA><NlmUniqueID>7608491</NlmUniqueID><ISSNLinking>0378-7966</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Indium Radioisotopes</NameOfSubstance></Chemical><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance>Tablets, Enteric-Coated</NameOfSubstance></Chemical><Chemical><RegistryNumber>362O9ITL9D</RegistryNumber><NameOfSubstance>Acetaminophen</NameOfSubstance></Chemical><Chemical><RegistryNumber>7440-26-8</RegistryNumber><NameOfSubstance>Technetium</NameOfSubstance></Chemical><Chemical><RegistryNumber>7A314HQM0I</RegistryNumber><NameOfSubstance>Pentetic Acid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName MajorTopicYN="N">Acetaminophen</DescriptorName><QualifierName MajorTopicYN="N">administration & dosage</QualifierName><QualifierName MajorTopicYN="N">chemistry</QualifierName><QualifierName MajorTopicYN="N">pharmacokinetics</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Biological Availability</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Drug Compounding</DescriptorName><QualifierName MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Gamma Cameras</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Indium Radioisotopes</DescriptorName><QualifierName MajorTopicYN="N">diagnostic use</QualifierName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Pentetic Acid</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Radionuclide Imaging</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Solubility</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="Y">Tablets, Enteric-Coated</DescriptorName></MeshHeading><MeshHeading><DescriptorName MajorTopicYN="N">Technetium</DescriptorName></MeshHeading></MeshHeadingList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1994</Year><Month>4</Month><Day>1</Day></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>1994</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>1994</Year><Month>4</Month><Day>1</Day><Hour>0</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">8001600</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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